Integrative Genomic Analysis In Cancer Essay - 783 Words

Other methodologies for integrative genomic analysis in cancer have been studied previously. The review presented in \cite{kristensen2014principles} summarizes a number of different tools and algorithms used in this area. The paper classifies these methods into statistical, machine learning, gene set, network, and other analysis techniques.\\ Many work has been done to perform an integrated analysis using genetic and gene expression data. In \cite{xiong2012integrating}, the authors illustrated that joint analyses of genomic data increase the power to detect real associations when compared with gene set methods that use only one genomic data type. They developed a single statistical framework, Gene Set Association Analysis†¦show more content†¦The authors of this paper integrated high-dimensional genetic and proteomic data in a cohort of subjects in which a portion experienced an adverse event (AE) after primary immunization with Aventis Pasteur smallpox vaccine. They modelle d the AE risk using 1442 single nucleotide polymorphisms as genetic variables and 108 serum cytokine concentrations as proteomic variables. They employed the Random Forests (RF) method to filter the most important attributes to be used in the building of a final decision tree model. After that, they built a comprehensive model of AE development by integrating information from previous studies with the genetic and proteomic attributes identified by RF. The biological factors included in the model support their hypothesized mechanism for the development of AEs involving prolonged stimulation of inflammatory pathways and an imbalance of normal tissue damage repair pathways. A novel approach was presented in \cite{zhong2010integrating}. This approach uses information from genetics of gene expression studies to investigate biological pathways enriched for expression-associated genetic loci related with disease in publicly available Genome-wide Association Studies (GWAS) results. The authors of this paper, first identified SNPs in population-based human cohorts that associate with the expression of genes (eSNPs) in the metabolically active tissues liver, subcutaneousShow MoreRelatedProject Mgmt296381 Words   |  1186 PagesLeadership Chapter 2 Organization Strategy and Project Selection 1.4 Projects and programs (.2) 1.4.1 Managing the portfolio 1.4.3 Strategy and projects 2.3 Stakeholders and review boards 12.1 RFP’s and vendor selection (.3.4.5) 11.2.2.6 SWAT analysis 6.5.2.7 Schedule compression 9.4.2.5 Leadership skills G.1 Project leadership 10.1 Stakeholder management Chapter 11 Teams Chapter 3 Organization: Structure and Culture 2.4.1 Organization cultures [G.7] 2.4.2 Organization structure